Factor V Leiden is not common in children with portal vein thrombosis.

A), known as factor V Leiden, has been identified and results in abnormal factor V product, resistant to proteolytic inactivation by activated protein C and thus predisposes to thrombosis. This study was carried out to verify if children with PVT have an increase in frequency of factor V Leiden. Allele-specific restriction analysis and single strand conformational polymorphism (SSCP) were used to test for factor V Leiden in 20 children with PVT and 64 normal children. None of the PVT children were heterozygous or homozygous for the factor V Leiden, and one control child was heterozygous. This study demonstrates that factor V Leiden is not common in children with PVT, and is not a prerequisite for this thrombotic event. -->
Komentáře: Comment in: Thromb Haemost. 1997 Oct;78(4):1297-8. (PMID: 9365003)
Substance Nomenclature: 0 (factor V Leiden)
9001-24-5 (Factor V)
Entry Date(s): Date Created: 19970201 Date Completed: 19970520 Latest Revision: 20041117
Update Code: 20240829
PMID: 9157577
Autor: Seixas CA; Department of Pediatrics, São Francisco University, Bragança Paulista, SP, Brazil., Hessel G, Ribeiro CC, Arruda VR, Annichino-Bizzacchi JM
Jazyk: angličtina
Zdroj: Thrombosis and haemostasis [Thromb Haemost] 1997 Feb; Vol. 77 (2), pp. 258-61.
Abstrakt: Portal vein thrombosis (PVT) is a rare condition affecting both children and adults, and occurs in association with a wide variety of clinical situations. On the other hand, the development of PVT in patients under these situations indicates that other contributing factors could be involved. Recently a missense mutation in the factor V gene (1691G-->A), known as factor V Leiden, has been identified and results in abnormal factor V product, resistant to proteolytic inactivation by activated protein C and thus predisposes to thrombosis. This study was carried out to verify if children with PVT have an increase in frequency of factor V Leiden. Allele-specific restriction analysis and single strand conformational polymorphism (SSCP) were used to test for factor V Leiden in 20 children with PVT and 64 normal children. None of the PVT children were heterozygous or homozygous for the factor V Leiden, and one control child was heterozygous. This study demonstrates that factor V Leiden is not common in children with PVT, and is not a prerequisite for this thrombotic event.
Databáze: MEDLINE
Externí odkaz: