| Autor: |
Bojanova E; Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria., Genkova-Papazova M, Petkova B, Lazarova-Bakarova M |
| Jazyk: |
angličtina |
| Zdroj: |
Methods and findings in experimental and clinical pharmacology [Methods Find Exp Clin Pharmacol] 1997 Mar; Vol. 19 (2), pp. 93-7. |
| Abstrakt: |
The effect of the Ca2+ blocker verapamil on amnesia induced by electroconvulsive shock (ECS) or by the alpha-adrenoceptor agonist clonidine was studied in male Wistar rats trained in passive avoidance task ("step down"). Clonidine (0.1 mg/kg, i.p.) and ECS induced a pronounced amnesia, significantly reducing the percentage of rats that had acquired the task upon retention tests, given 3 h, 24 h and 7 days after training. Verapamil (10 mg/kg) administered orally for 12 days (5 days before and 7 days after training) completely abolished the ECS- or clonidine-induced amnesia. These data suggest that calcium channel blocker verapamil has a protective effect against experimentally provoked memory deficit and might be useful for the treatment of cognitive disorders. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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