| Autor: |
Heinzel T; Howard Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla 92093-0648, USA., Lavinsky RM, Mullen TM, Söderstrom M, Laherty CD, Torchia J, Yang WM, Brard G, Ngo SD, Davie JR, Seto E, Eisenman RN, Rose DW, Glass CK, Rosenfeld MG |
| Jazyk: |
angličtina |
| Zdroj: |
Nature [Nature] 1997 May 01; Vol. 387 (6628), pp. 43-8. |
| DOI: |
10.1038/387043a0 |
| Abstrakt: |
Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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