| Autor: |
Maran R; Department of Medicine 'B', Chaim Sheba Medical Center, Tel-Hashomer, Israel., Dueymes M, Le Corre R, Renaudineau Y, Shoenfeld Y, Youinou P |
| Jazyk: |
angličtina |
| Zdroj: |
Annales de medecine interne [Ann Med Interne (Paris)] 1997; Vol. 148 (1), pp. 29-38. |
| Abstrakt: |
IgG comprises of four subclasses which differ from each other with respect to their biological properties. Fc gamma receptor shedding as well as a variety of T cell cytokines are influential in the distribution of these subclasses, but the route the antigen is introduced into the body is also important. With regard to nonorgan-specific autoimmune conditions, such as rheumatoid arthritis and systemic lupus erythematosus, IgG1 and IgG3 autoantibodies predominate, whereas IgG4 antibodies are regularly encountered in organ-specific autoimmune diseases. This suggests that the target organ may be continuously stimulating the immune system. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
