Hepatocellular necrosis associated with the subcutaneous injection of an intranasal Bordetella bronchiseptica-canine parainfluenza vaccine.

Autor: Toshach K; Department of Medical Sciences, Veterinary of Medical Teaching Hospital, University of Wisconsin-Madison 53706, USA., Jackson MW, Dubielzig RR
Jazyk: angličtina
Zdroj: Journal of the American Animal Hospital Association [J Am Anim Hosp Assoc] 1997 Mar-Apr; Vol. 33 (2), pp. 126-8.
DOI: 10.5326/15473317-33-2-126
Abstrakt: A three-year-old wire fox terrier inadvertently was given an intranasal Bordetella bronchiseptica and canine parainfluenza vaccine subcutaneously. The dog subsequently developed both a local inflammatory reaction at the injection site and acute, nonseptic hepatocellular degeneration and necrosis. The patient was treated successfully with intravenous fluids and amikacin. Two months after the injection, the serum bile acid concentrations and hepatic histopathology indicated the presence of continued hepatocellular disease.
Databáze: MEDLINE