The inhibitory effect of vitamin E on K-ras mutation at an early stage of lung carcinogenesis in mice.

T mutation at an early stage of urethane-induced lung carcinogenesis in mice. Thirty days after urethane injection, the K-ras mutation was detected in 64% of lung samples tested by mutant-allele-specific amplification. The consumption of a supplemented diet with about 20-times more vitamin E than the control diet, only during the promotion phase or during both the initiation and promotion phases of lung carcinogenesis, reduced the frequency of the mutation to 36 and 18%, respectively. Also, vitamin E suppressed the level of proliferating cell nuclear antigen as a marker of cell proliferation in the lungs of mice treated with urethane. These results support the notion that vitamin E is a useful chemopreventive agent against lung cancer. -->
Substance Nomenclature: 1406-18-4 (Vitamin E)
3IN71E75Z5 (Urethane)
Entry Date(s): Date Created: 19970326 Date Completed: 19970708 Latest Revision: 20190624
Update Code: 20221213
DOI: 10.1016/s0014-2999(97)00094-0
PMID: 9105883
Autor: Yano T; Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan. yano@nih.go.jp, Uchida M, Yuasa M, Murakami A, Hagiwara K, Ichikawa T
Jazyk: angličtina
Zdroj: European journal of pharmacology [Eur J Pharmacol] 1997 Mar 26; Vol. 323 (1), pp. 99-102.
DOI: 10.1016/s0014-2999(97)00094-0
Abstrakt: In this study, we investigated the effect of vitamin E on the activation of the K-ras oncogene with a 61st codon A-->T mutation at an early stage of urethane-induced lung carcinogenesis in mice. Thirty days after urethane injection, the K-ras mutation was detected in 64% of lung samples tested by mutant-allele-specific amplification. The consumption of a supplemented diet with about 20-times more vitamin E than the control diet, only during the promotion phase or during both the initiation and promotion phases of lung carcinogenesis, reduced the frequency of the mutation to 36 and 18%, respectively. Also, vitamin E suppressed the level of proliferating cell nuclear antigen as a marker of cell proliferation in the lungs of mice treated with urethane. These results support the notion that vitamin E is a useful chemopreventive agent against lung cancer.
Databáze: MEDLINE
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