Breast tumor diagnosis in cytologic aspirates using monoclonal antibodies to keratin 8 and 17.
| Autor: | Kirjushkina MS; Department of Human Pathology, Russian Academy of Medical Sciences, Moscow, Russia., Tchipysheva TA, Ermilova VD, Guelstein VI |
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| Jazyk: | angličtina |
| Zdroj: | Acta cytologica [Acta Cytol] 1997 Mar-Apr; Vol. 41 (2), pp. 307-12. |
| DOI: | 10.1159/000332517 |
| Abstrakt: | Objective: To determine the effect of double immunostaining in the differential diagnosis of the benign vs. malignant nature of breast lesions with fine needle aspiration results. Study Design: The study group consisted of 26 samples aspirated from patients with borderline breast lesions. Results: Direct immunostaining by means of monoclonal antibodies directed against individual intermediate filament proteins keratin 8 and 17 revealed that the percentage of K8+K17+ cells in material from patients with fibrocystic disease and fibroadenoma significantly exceeded that found in carcinoma specimens. The diagnoses were confirmed histologically. Conclusion: The quantitative method applied in the analysis of double-immunostained cytologic aspirates is recommended for the differential diagnosis of the benign vs. malignant nature of breast lesions in borderline cases. |
| Databáze: | MEDLINE |
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