| Autor: |
Giovenardi M; Department of Physiology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Padoin MJ, Cadore LP, Lucion AB |
| Jazyk: |
angličtina |
| Zdroj: |
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 1997 Jan 15; Vol. 807, pp. 606-9. |
| DOI: |
10.1111/j.1749-6632.1997.tb51981.x |
| Abstrakt: |
Both the lesion of the parvocellular region of the PVN (FIG. 1) and the acute reduction of OT synthesis in that nucleus (FIG. 2) increase maternal aggression in rats. Previous work showed that ibotenic acid as well as the OT antisense in the PVN reduced the level of OT in the brainstem, but not in the pituitary. Therefore, the oxytocinergic parvocellular neurons of the PVN appear to exert an inhibitory effect on the aggressive behavior of the lactating female rat against an adult intruder. In a relationship of a different nature, mother-infant, a facilitatory effect of OT has been shown. Previous work showed a significant decrease of OT mRNA levels in the PVN of female rats during the first 10 days after delivery compared to late pregnancy, which is the inverse ratio of the natural temporal evolution of maternal aggressive behavior. Furthermore, in the present work, a functional decrease of OT mRNA was probably the effect of the antisense in the PVN. In conclusion, OT cells in the PVN appear to play different roles on maternal care and maternal aggression. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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