| Autor: |
Lankester AC; Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, University of Amsterdam, The Netherlands., Schijndel GM, Pakker NG, Van Oers RH, van Lier RA |
| Jazyk: |
angličtina |
| Zdroj: |
Leukemia & lymphoma [Leuk Lymphoma] 1996 Dec; Vol. 24 (1-2), pp. 27-33. |
| DOI: |
10.3109/10428199609045711 |
| Abstrakt: |
Functional studies revealed that two groups of B chronic lymphocytic leukemia (B-CLL) can be distinguished based on their capacity to mount a proliferative response following B-cell antigen receptor (BCR) cross-linking. The molecular basis for the functional distinction between these B-CLL groups most probably resides within or proximal to the BCR since non-responsive B-CLL, in marked contrast to responsive B-CLL, do not respond to BCR ligation with tyrosine phosphorylation of cellular substrates and increases in the free intracellular [Ca++]. Detailed biochemical analysis showed overall structural identity between responsive and non-responsive B-CLL with respect to both transmembrane and intracellular associates of the BCR complex. However expression levels of the protein tyrosine kinase syk, which is a key enzyme for the early signalling through the BCR, were found to be markedly lower in non-proliferating B-CLL. Here we will review current functional and biochemical data on responding and non-responding B-CLL and discuss the relevance of these findings for disease progression and our insight into the immunobiology of B-CLL. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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