| Autor: |
Lindsay CK; Laboratory of Cellular Carcinogenesis and Tumor Promotion, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Thorgeirsson UP, Tsuda H, Hirohashi S |
| Jazyk: |
angličtina |
| Zdroj: |
Human pathology [Hum Pathol] 1997 Mar; Vol. 28 (3), pp. 359-66. |
| DOI: |
10.1016/s0046-8177(97)90136-2 |
| Abstrakt: |
The relationship between malignant epithelial cell growth and the formation of tumor stroma is poorly understood. To investigate the roles of type IV collagenases/gelatinases and tissue inhibitor of metalloproteinase-1 (TIMP-1) in human breast cancer, we localized their messenger RNAs (mRNAs) in normal and malignant breast tissue. Type IV collagenase/gelatinase mRNAs were expressed at low levels by some tumor cells. High levels of TIMP-1 mRNA were found in all areas where tissue remodeling was evident, particularly in cells at the tumor-stromal interface. Small blood vessels in both the tumor and stroma were often outlined by high levels of TIMP-1 mRNA. These results indicate that TIMP-1 and type IV collagenases/gelatinases are expressed independently in breast cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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