| Autor: |
Rodriguez C; Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903, USA., Bugay DE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pharmaceutical sciences [J Pharm Sci] 1997 Feb; Vol. 86 (2), pp. 263-6. |
| DOI: |
10.1021/js960286z |
| Abstrakt: |
The combined physical analytical technique of thermogravimetric and infrared analysis (TG/IR) is described for the investigation of pharmaceutical solids. TG/IR provides an unequivocal identification of the volatile content of a pharmaceutical solid. In the case of pharmaceutical solvates, TG/IR provides identification of the evolved gas from the crystalline solid. Variable temperature X-ray diffraction and differential scanning calorimetry techniques provide the required information to ascertain whether the evolved gas was due to a solvent incorporated into the crystal lattice or physically adsorbed onto the solid. This work illustrates three examples of TG/IR as utilized in a multidisciplinary approach to the physical characterization of pharmaceutical solids. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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