| Autor: |
Reiss JO; Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA., Burd GD |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neurobiology [J Neurobiol] 1997 Feb; Vol. 32 (2), pp. 213-22. |
| DOI: |
10.1002/(sici)1097-4695(199702)32:2<213::aid-neu6>3.0.co;2-b |
| Abstrakt: |
In adult Xenopus, the nasal cavity is divided into separate middle (MC) and principal (PC) cavities; the former is used to smell water-borne odorants, the latter air-borne odorants. Recent work has shown that olfactory neurons of each cavity express a distinct subclass of odorant receptors. Moreover, MC and PC axons project to distinct regions of the olfactory bulb. To examine the developmental basis for this specificity in the olfactory projection, we extirpated the developing MC from early metamorphic (stage 54-57) tadpoles and raised the animals through metamorphosis. In most lesioned animals, the MC partly regenerated. Compared with the unlesioned side, reduction of the region of the glomerular layer of the olfactory bulb receiving MC afferents ranged from 70% to 95%. PC afferents did not occupy regions of the olfactory bulb deprived of MC afferents. These results support a model in which intrinsic cues in the olfactory bulb control the projection pattern attained by ingrowing olfactory axons. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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