[New approaches to determining the type classification of presynaptic acetylcholine receptors].

Autor: Kosmachev AB, Filippov VN, Podosinovikova NP, Gorobets LF, Dolgo-Saburov VB, Libman NM, Solov'eva NE
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 1996 Sep-Oct; Vol. 59 (5), pp. 3-5.
Abstrakt: A complex of special tests which took into account the coupling of the specific physiological responses with individual subtypes of muscarinic cholinoceptors, and radioligand analysis showed the predominance of M3- and M2-subtype presynaptic receptors in the rat brain hemispheres. The autoreceptors regulating the presynaptic release of acetylcholine are related mainly to the M2-subtype and account for the smaller part of the mixed population of presynaptic receptors.
Databáze: MEDLINE