| Autor: |
Lottering ML; Department of Physiology, Faculty of Medicine, University of Pretoria, South Africa., de Kock M, Viljoen TC, Grobler CJ, Seegers JC |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 1996 Dec 20; Vol. 110 (1-2), pp. 181-6. |
| DOI: |
10.1016/s0304-3835(96)04489-8 |
| Abstrakt: |
The activity of p34(cdc2) plays a key role in the regulation of the eukaryotic cell cycle. Another cell cycle associated molecule is PCNA. We investigated the effects of 2-hydroxy-17beta-estradiol, a cell proliferator, and 2-methoxy-17beta-estradiol, a potent inhibitor of cell growth, on the levels and activity of p34(cdc2) and on the levels of PCNA, as well as on protein phosphorylation in MCF-7 cells. 2-Hydroxyestradiol increased p34(cdc2) activity at G1/S and elevated PCNA levels during S-phase. 2-Methoxyestradiol caused unscheduled activation of p34(cdc2) in S-phase and decreased levels of p34(cdc2) and PCNA during G2/M. We conclude that 2-hydroxy- and 2-methoxyestradiol have definite, though different regulatory functions during the cell cycle. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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