High levels of Gs alpha in platelets of euthymic patients with bipolar affective disorder.
| Autor: | Mitchell PB; Experimental Therapeutics Branch, NIMH, Bethesda, Md., USA. phil.mitchell@unsw.edu.au, Manji HK, Chen G, Jolkovsky L, Smith-Jackson E, Denicoff K, Schmidt M, Potter WZ |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The American journal of psychiatry [Am J Psychiatry] 1997 Feb; Vol. 154 (2), pp. 218-23. |
| DOI: | 10.1176/ajp.154.2.218 |
| Abstrakt: | Objective: Previous investigations have suggested the involvement of signal-transducing guanine-nucleotide-binding proteins (G proteins) both in the mechanism of action of lithium and in the pathophysiology of bipolar affective disorder. To determine whether such G protein abnormalities are a trait phenomenon, the authors investigated the levels of G protein alpha subunits in platelets and lymphocytes of euthymic patients with bipolar affective disorder. Method: Selective antibodies were used to quantitate levels of G protein alpha subunits regulating adenylylcyclase activity (Gs alpha-both 45- and 52-kDa forms- and Gil-2 alpha) and those regulating phosphoinositide turnover (Gq/11 alpha) in both platelets and lymphocytes of 44 euthymic patients with bipolar affective disorder and 27 matched comparison subjects. Results: Levels of both Gs alpha 45 and Gs alpha 52 were higher in the platelets of the euthymic bipolar patients (both bipolar I and bipolar II) than in those of the comparison subjects. Conclusions: These findings are consistent with previous reports of high Gs alpha levels in bipolar affective disorder and, furthermore, suggest that such levels may be a trait abnormality for this condition. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|