| Autor: |
Cunningham ST; Institute of Animal Behavior, State University of New Jersey, Newark, USA., Finn M, Kelley AE |
| Jazyk: |
angličtina |
| Zdroj: |
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 1997 Feb; Vol. 16 (2), pp. 147-55. |
| DOI: |
10.1016/S0893-133X(96)00166-2 |
| Abstrakt: |
The following experiments were performed to ascertain the role of the nucleus accumbens in opiate-dopamine interactions using measures of locomotor activity. Three separate experiments were carried out. In Experiment 1, rats received systemic morphine (10 mg/kg IP) or saline (1 ml/kg IP) every other day for 5 days, followed by systemic amphetamine (1.5 mg/kg) 48 hours following the fifth injection. Animals in the morphine pretreatment group exhibited a sensitized locomotor response to amphetamine. In Experiment 2, animals received the same systemic pretreatment and were subsequently given intraaccumbens saline, amphetamine (2.5 micrograms/0.5 microliter) or cocaine (7 micrograms/0.5 microliter), each separated by 48 hours. Morphine-pretreated animals showed enhanced motor activity in response to intraaccumbens microinfusion of the psychostimulant drugs. Finally, in Experiment 3, multiple microinjections of morphine (0.5 microgram/0.5 microliter) directly into the nucleus accumbens resulted in a potentiated locomotor response to intraaccumbens amphetamine (2.5 micrograms/0.5 microliter). These data indicate that the nucleus accumbens may contribute to both the development and expression of opiate-stimulant cross-sensitization. The neural basis of this sensitization is hypothesized to be a common intracellular pathway affected by both classes of drugs, such as the cyclic adenosine monophosphate (AMP) system. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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