[Comparative investigation of anticonvulsive effects of putrescine and structural analogues of delta-sleep-inducing peptide].

Autor: Uskova NI; NII of Neurocybernetics of AV Kogan, Rostov-Na-Donu., Lysenko AV, Mendzheritskii AM
Jazyk: ruština
Zdroj: Vestnik Rossiiskoi akademii meditsinskikh nauk [Vestn Ross Akad Med Nauk] 1996 (9), pp. 27-30.
Abstrakt: Intracysternal putrescine before a session of hyperbaric oxygenation (0.7 MPa) was shown to be more effective in prolonging the latent period of onset of generalized convulsive activity than intraperitoneal delta-sleep-inducing peptide or its structural analogues ID-1 or ID-3. Biochemical studies indicated that putrescine was also more effective in preventing hyperbaric oxygenation-induced decreases in the levels of GABA and homocarnosine in the brain and the accumulation of lipid peroxidation products in the brain and serum.
Databáze: MEDLINE