| Autor: |
Lephart ED; Department of Zoology, Brigham Young University, Provo, UT 84602, USA. edlephar@acd1.byu.edu, Ladle DR, Jacobson NA, Rhees RW |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research [Brain Res] 1996 Nov 11; Vol. 739 (1-2), pp. 356-60. |
| DOI: |
10.1016/s0006-8993(96)01068-2 |
| Abstrakt: |
Medial basal hypothalamic (MBH) 5 alpha-reductase activity was significantly blocked with a known inhibitor, Proscar (Finasteride), in pregnant rats while their open-field behavior was quantified during the last week of pregnancy. In control animals, open-field behavior significantly decreased (in a stair-step fashion) as a function of increasing gestational age. Conversely, in Proscar-treated animals open-field values significantly increased on day 15 and 17 of gestation compared to control values. These data indicate that inhibition of MBH 5 alpha-reductase during pregnancy significantly increased open-field activity levels during late gestation in rats and provides evidence for a link between the production of 5 alpha-reduced metabolites of progesterone in brain and behavioral activity during pregnancy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect