| Autor: |
Hérault J; Laboratoire de Biochimie et de Biologie Moléculaire, INSERM U 316, CHRU Bretonneau, Tours, France., Petit E, Martineau J, Cherpi C, Perrot A, Barthélémy C, Lelord G, Müh JP |
| Jazyk: |
angličtina |
| Zdroj: |
Psychiatry research [Psychiatry Res] 1996 Nov 01; Vol. 65 (1), pp. 33-43. |
| DOI: |
10.1016/0165-1781(96)02882-x |
| Abstrakt: |
Whole blood and urinary levels of serotonin (5-hydroxytryptamine; 5-HT) and the derivative urinary 5-hydroxyindoleacetic acid (5-HIAA) were measured in normal and autistic subjects. An association was tested between autism and a marker coding for the 5-HT2A serotonergic receptor gene. Significant group (high urinary 5-HT and low whole blood 5-HT in autism) and age effects (urinary 5-HT decrease with age) were found. Moreover, whole blood 5-HT levels were correlated with clinical state. No differences in allele and genotype frequencies for the 5-HT2A receptor marker were found in this autistic population compared with age-matched healthy students. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full Text from ScienceDirect