| Autor: |
Kokoshka JM; Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 84112, USA., Capson TL, Holden JA, Ireland CM, Barrows LR |
| Jazyk: |
angličtina |
| Zdroj: |
Anti-cancer drugs [Anticancer Drugs] 1996 Sep; Vol. 7 (7), pp. 758-65. |
| DOI: |
10.1097/00001813-199609000-00007 |
| Abstrakt: |
Wakayin is bispyrroloiminoquinone isolated from a Clavelina sp. ascidian by cytotoxicity directed fractionation. Like camptothecin, it has been found to inhibit the topoisomerase I catalyzed relaxation of supercoiled DNA. Wakayin enhanced cleavage complex formation at the same DNA sequences as camptothecin. Both compounds showed dose-related increases in cleavage complex formation, though wakayin's effect is attenuated at high concentrations. Wakayin is a string DNA binder. Wakayin also differed from camptothecin in that its cleavage complexes were much less stable than those of camptothecin in 0.5 M NaCl. Again in contrast to camptothecin, wakayin stabilized cleavage complexes poorly, if at all, at 0 degree C. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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