| Autor: |
Jensen EM, LaPolla RJ, Kirby PE, Haworth SR |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the National Cancer Institute [J Natl Cancer Inst] 1977 Sep; Vol. 59 (3), pp. 941-4. |
| DOI: |
10.1093/jnci/59.3.941 |
| Abstrakt: |
A quantitative microbial assay was used to study the stability of known mutagenic and carcinogenic compounds in cell culture medium. Ten direct-acting carcinogens, when incubated in culture medium with 15% fetal bovine serum at pH 7.2-7.4 and 37 degrees C, became inactive at varying rates. Biologic half-lives of the test compounds ranged from 8 minutes to 67 hours. In contrast, six procarcinogens showed no significant inactivation after 3 weeks' incubation. The biologic half-lives of each compound were presented, and the significance of these findings as they relate to cell culture carcinogenesis and mutagenesis assays was discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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