| Autor: |
Brain EG, Eglington AJ, James BG, Nayler JH, Osborne NF, Pearson MJ, Smale TC, Southgate R, Tolliday P, Basker MJ, Mizen LW, Sutherland R |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1977 Aug; Vol. 20 (8), pp. 1086-90. |
| DOI: |
10.1021/jm00218a019 |
| Abstrakt: |
A previously outlined general procedure for preparing various 3-substituted cephalosporins from the penicillin nucleus has been used, with modifications where required, to prepare a series of analogues of cephalexin with various substituents in the 3-methyl group. The 3-substituents most conducive to broad-spectrum antibacterial activity were 3-pyridylmethyl and m- or p-carboxybenzyl. The compounds were only poorly absorbed by the oral route in mice, but the 3-(carboxybenzyl) compounds gave more prolonged useful serum levels than the usual cephalosporins. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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