| Autor: |
Jones TE; Department of Pharmacy, Queen Elizabeth Hospital, Woodville, South Australia., Morris RG, Saccoia NC, Thorne D |
| Jazyk: |
angličtina |
| Zdroj: |
Palliative medicine [Palliat Med] 1996 Oct; Vol. 10 (4), pp. 313-7. |
| DOI: |
10.1177/026921639601000407 |
| Abstrakt: |
The extent of absorption and other pharmacokinetic parameters of dextromoramide following sublingual administration were assessed in five patients receiving chronic opioid analgesia. The use of the standard 5 mg tablet formulation was associated with negligible absorption in two patients, a prolonged time to peak concentration in the other three and substantial variability in clearance. The study concluded that the standard tablet formulation cannot be recommended for sublingual use where reliable, rapid onset analgesia is required. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
