| Autor: |
Ereshefsky L; University of Texas at Austin, USA., Riesenman C, True JE, Javors M |
| Jazyk: |
angličtina |
| Zdroj: |
Psychopharmacology bulletin [Psychopharmacol Bull] 1996; Vol. 32 (1), pp. 101-6. |
| Abstrakt: |
Stimulating the platelet 5HT2 receptor generates the second messenger IP3, and results in an increase in cytosolic [Ca++] ([Ca++]cyt). Platelets from risperidone-treated patients would be expected to respond less effectively, as measured by decreased [Ca++]cyt, after 5HT2 receptor stimulation. We report the data on 6 risperidone-treated patients and 6 normal controls evaluated at our site using the Fura-2 method for determining platelet [Ca++]. Data analysis was performed by unpaired two-tailed Student's t-test. No significant differences between groups were found for ED50 5HT-stimulated [Ca++]cyt (ED50 5HT delta [Ca++]cyt). Significant differences were found for maximal change [Ca++]cyt (Max delta [Ca+2]cyt) between risperidone-treated patients and normal controls (p = .03). These preliminary data suggest that measurement of 5HT-stimulated changes in platelet cytosolic [Ca+2] might be a useful marker for in vivo risperidone inhibition of 5HT2 function. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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