Autor: |
Roth KD; Chemistry Department, Michigan State University, East Lansing 48824-1322, USA., Siegel NA, Johnson RW Jr, Litauszki L, Salvati L Jr, Harrington CA, Wray LK |
Jazyk: |
angličtina |
Zdroj: |
Journal of analytical toxicology [J Anal Toxicol] 1996 Sep; Vol. 20 (5), pp. 291-300. |
DOI: |
10.1093/jat/20.5.291 |
Abstrakt: |
The loss of 11-nor-delta 9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) from solution was studied using fluorescence polarization immunoassay (FPIA) technology and x-ray photoelectron spectroscopy (XPS). Several materials (glass, silylated glass, high density polyethylene, polypropylene, polystyrene, polymethylmethacrylate, Teflon, and Kynar) were studied along with three solvents (water, urine, and Abbott cannabinoids diluent). THC-COOH losses ranging from 0 to 9.7 ng/cm2 and concentration reductions to 46% of starting values were measured. XPS indicated the presence of fluorine-labeled THC-COOH at materials surfaces. A half-life of 10 min was calculated for THC-COOH loss from urine stored in high density polyethylene at room temperature. Sample handling losses during pipetting were determined and ranged from 1.1 to 7.9 ng per aliquot. The effects of sample volume and sample handling on the THC-COOH concentrations of controls were also investigated. |
Databáze: |
MEDLINE |
Externí odkaz: |
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