Premature aging in persons with Down syndrome: MR findings.

Autor:	Roth GM; Department of Radiological Sciences, University of California, Irvine Medical Center, Orange 92668, USA., Sun B, Greensite FS, Lott IT, Dietrich RB
Jazyk:	angličtina
Zdroj:	AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 1996 Aug; Vol. 17 (7), pp. 1283-9.
Abstrakt:	Purpose: To determine whether persons with Down syndrome have features of premature aging on routine MR imaging sequences. Methods: Sixty MR studies (in 30 persons with Down syndrome and 30 age- and sex-matched control subjects) were reviewed retrospectively by two blinded examiners. Sagittal T1-weighted and axial T2-weighted spin-echo images were evaluated for the presence and severity of three markers of brain aging: atrophy, white matter lesions, and T2 hypointensity of the basal ganglia, referenced to the examiner's internal standard of normal for that age and sex. Results: Persons with Down syndrome had higher prevalence and severity of the three markers studied than the control subjects. Atrophy and white matter lesions increased in prevalence with age; abnormal T2 hypointensity of the basal ganglia was more equally distributed with age. Conclusion: Persons with Down syndrome have features of premature aging detectable at routine MR imaging.
Databáze:	MEDLINE
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