| Autor: |
Reed RK; Department of Medical and Physiological Chemistry, University of Uppsala, Sweden., Laurent UB, King S, Fraser JR, Laurent TC |
| Jazyk: |
angličtina |
| Zdroj: |
Acta physiologica Scandinavica [Acta Physiol Scand] 1996 Feb; Vol. 156 (2), pp. 93-8. |
| DOI: |
10.1046/j.1365-201X.1996.471185000.x |
| Abstrakt: |
The removal rate of high molecular weight (M(r) 3 x 10(6) [3H]hyaluronan has been measured in rabbit paw skin in control and during increased local venous pressure induced by ligation of the femoral vein. The increased venous pressure resulted in a 20% increase of interstitial volume at 4 h after ligation, a value which relates to at least a doubling of lymph flow, i.e. also to doubling of fluid flux through the tissues. The fractional catabolic rate of hyaluronan was 0.0918 +/- 0.0170 h-1 (n = 10) and 0.0775 +/- 0.0206 h-1 (n = 11) in control and following increased venous pressure respectively (P > 0.05). Since the fractional catabolic rate of hyaluronan is not affected by increased venous pressure, the removal of hyaluronan via lymphatic drainage in rabbit paw skin must be small compared to the local turnover of the polysaccharide. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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