Lithium blocks 45Ca2+ uptake into platelets in bipolar affective disorder and controls.

Autor: Berk M; Department of Psychiatry, University of the Witwatersrand Medical School, Johannesburg, South Africa., Kirchmann NH, Butkow N
Jazyk: angličtina
Zdroj: Clinical neuropharmacology [Clin Neuropharmacol] 1996 Feb; Vol. 19 (1), pp. 48-51.
DOI: 10.1097/00002826-199619010-00002
Abstrakt: The basal uptake of radiolabelled 45Ca2+ into platelets and the effect of 1 mM lithium on uptake was measured in manic (n = 13) and depressed (n = 15) patients with bipolar disorder and in controls (n = 13). Lithium was significantly associated with inhibition of uptake of 45Ca2+ into platelets in all three groups. There were no significant intergroup differences in either basal levels of calcium uptake or the effects of lithium on calcium uptake (analysis of variance).
Databáze: MEDLINE