Interrelation between two anticomplement cobra venom factors isolated from crude Naja naja cobra venom.

Autor: Johnson BJ, Kucich UN
Jazyk: angličtina
Zdroj: Journal of pharmaceutical sciences [J Pharm Sci] 1977 Jul; Vol. 66 (7), pp. 947-9.
DOI: 10.1002/jps.2600660711
Abstrakt: Two moieties occurring in crude Naja naja cobra venom were found to possess anticomplement activity. Both materials possessed similar molecular weights and specific activities but dissimilar elution profiles upon ion-exchange chromatography. The anticomplement activities of these materials were maintained upon digestion with neuraminidase, and their elution profiles from cation-exchange chromatography became identical after this treatment. It was concluded that the differences between the two anticomplement materials were due to their different sialic acid contents.
Databáze: MEDLINE
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