| Autor: |
Turusov VS; Cancer Research Centre, Russian Academy of Medical Sciences, Moscow., Kolesnichenko TS, Gor'kova TG |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie [Exp Toxicol Pathol] 1995 Sep; Vol. 47 (4), pp. 244-6. |
| DOI: |
10.1016/S0940-2993(11)80258-7 |
| Abstrakt: |
Perinatal lung carcinogenesis in susceptible (A) and resistant (C57B1/6J) to lung carcinogenesis mice was studied in (1) experiment in vivo and (2) in organ cultures of embryonic lung exposed to carcinogens directly (in vitro) or transplacentally (in utero): females were treated with carcinogens at 17-19 days of pregnancy, killed 1-2 days after the treatment and embryonic lungs were explanted in organ cultures. Transplacental and direct (in vitro) treatment with urethane and benz(a)pyrene (BP) induced in the explants: (1) stimulation of epithelial and mesenchymal cell proliferation; (2) increase of viability and survival as compared to the non-treated explants (growth stimulating effect); (3) morphological lesions (hyperplasia and squamous-cell metaplasia of epithelium, adenomatous growth and adenoma-like structures). All the alterations developed in treated lung explants depended both on host factors and carcinogenic treatment (type of carcinogen, dose, method of exposure, and duration of cultivation). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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