| Autor: |
Ojo B; Department of Medicinal Chemistry, School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0540, USA., Findsen LA, Igarashi N, Kong B, Chowdhury BK |
| Jazyk: |
angličtina |
| Zdroj: |
Drug design and discovery [Drug Des Discov] 1996 Mar; Vol. 14 (1), pp. 1-14. |
| Abstrakt: |
As part of a continuing effort aimed at the development of efficacious antihistaminic and bronchodilator agents for the treatment of asthma and related respiratory diseases, a series of novel trisubstituted deoxyvasicine derivatives was designed and synthesized. Bronchodilatory activity of pure samples of ligands 17a-d, and DL-8-chlorovasicine hydrochloride is investigated and compared with isoprenaline and aminophylline. These studies confirm the activity of ligands 17a-d and the potentiating effect of 17c on aminophylline. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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