| Autor: |
Bakalova R; Department of Medical Physics and Biophysics, High University School of Medicine, Sofia, Bulgaria., Goudev A, Zhelev Z, Nachev C |
| Jazyk: |
angličtina |
| Zdroj: |
Acta physiologica et pharmacologica Bulgarica [Acta Physiol Pharmacol Bulg] 1995; Vol. 21 (4), pp. 81-5. |
| Abstrakt: |
Oxidative modifications of blood serum in humans with and without coronary artery disease were investigated. Four parameters were analyzed: the intensity of serum fluorescence, which is indicative of the content of lipofuscine-like lipid peroxidation products; the content of thiobarbituric acid-reactive substances; the lag-phase of serum oxidation by azo-compounds; and the content of lipophilic natural antioxidants--alpha-tocopherol, beta-carotene and ubiquinol-9(10). It was found that coronary artery disease resulted in a significant increase of serum fluorescence and the content of TBARS. The atherogenic disorders in humans with coronary artery disease drastically decreased the lag-phase of serum oxidation in the presence of 2,2'-azo-bis-(2-amidinopropane) dihydrochloride. The oxidative modifications of serum were in close correlation with the balance of natural lipophilic antioxidants in blood serum, i.e. alpha-tocopherol, ubiquinols and beta-carotene. The contents of all antioxidants tested in serum were significantly decreased in patients with coronary artery disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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