| Autor: |
Sing CF; Department of Human Genetics, School of Medicine, University of Michigan, Ann Arbor 48109-0618, USA., Haviland MB, Reilly SL |
| Jazyk: |
angličtina |
| Zdroj: |
Ciba Foundation symposium [Ciba Found Symp] 1996; Vol. 197, pp. 211-29; discussion 229-32. |
| DOI: |
10.1002/9780470514887.ch12 |
| Abstrakt: |
The purpose of this paper is to foster a dialogue among those interested in the genetic analysis of common chronic diseases. The need for an alternative to the Cartesian-Mendelian research strategy is discussed. A biological model that considers an individual's health to be an emergent property of a complex adaptive system is presented. A review of the contribution of the gene coding for apolipoprotein E to the genetic architecture of measures of lipid metabolism documents that an individual's coronary artery health has all the features expected of a complex adaptive system. Suggestions for enhancing our ability to use genetic information to predict onset, progression and severity of disease are offered. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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