| Autor: |
Qu YZ; Department of Pharmacology, Inner Mongolia Medical College, Huhhot, China., Wang YE, Li XX |
| Jazyk: |
angličtina |
| Zdroj: |
Methods and findings in experimental and clinical pharmacology [Methods Find Exp Clin Pharmacol] 1996 Jun; Vol. 18 (5), pp. 297-300. |
| Abstrakt: |
Thiofedrine inhibited rat platelet aggregation and intraplatelet thromboxane B2 (TxB2) generation induced by arachidonic acid. The IC50 values were 0.18 and 0.21 mmol/l, respectively. Thiofedrine, 1.25-5.00 mg/kg i.v., showed a significant inhibition of rat platelet aggregation and intraplatelet TxB2 generation induced by arachidonic acid, with ID50 values of 2.4 and 3.3 mg/kg. Thiofedrine, 0.5-2.0 mg/kg i.v., reduced TxB2 generation but increased 6-keto-PGF1 alpha formation in rat plasma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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