| Autor: |
Evans DM; Ferring Research Institute, University of Southampton Research Centre, UK., Jones DM, Pitt GR, Ashworth D, De Clerck F, Verheyen F, Szelke M |
| Jazyk: |
angličtina |
| Zdroj: |
Immunopharmacology [Immunopharmacology] 1996 May; Vol. 32 (1-3), pp. 117-8. |
| DOI: |
10.1016/0162-3109(95)00069-0 |
| Abstrakt: |
We have developed a series of novel, potent low molecular weight (4-600 Da) inhibitors of TK which were stable to cleavage by the enzyme and showed a high degree of selectivity for TK over several other serine proteases. Compound 7 (CH-2856) was found to reduce eosinophilia in a model of allergic inflammation. The effects observed in vivo provide further evidence for the involvement of TK and kinins in the pathophysiology of allergic diseases such as asthma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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