| Autor: |
Ramboz S; Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA., Saudou F, Amara DA, Belzung C, Segu L, Misslin R, Buhot MC, Hen R |
| Jazyk: |
angličtina |
| Zdroj: |
Behavioural brain research [Behav Brain Res] 1996; Vol. 73 (1-2), pp. 305-12. |
| DOI: |
10.1016/0166-4328(96)00119-2 |
| Abstrakt: |
Serotonin is a neuromodulator that is involved in a number of mood disorders such as depression, anxiety and impulsive violence. In an attempt to dissect the contribution of individual 5-HT receptor subtypes to behavior, we have generated by homologous recombination, mutant mice lacking the 5-HT1B receptor. These mice did not exhibit any obvious developmental or behavioral defect. However, the hyperlocomotor effect of the 5-HT1A/1B agonist, RU 24969 was completely absent in mutant mice, indicating that this effect is mediated by 5-HT1B receptors. Moreover, when confronted with an intruder, isolated mutant mice attacked the intruder faster and more intensely than wild-type mice, suggesting an involvement of 5-HT1B receptors in the modulation of aggressive behavior. These data might be related to the fact that a class of 5-HT1 agonists, termed serenics, have anti-aggressive properties, and with the findings that certain impulsive aggressive behaviors are associated with deficits in central serotonin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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