| Autor: |
Herrmann ME; Department of Surgery and Pathology, SUNY at Stony Brook, USA., Lalley PA, Rydstedt LL, Meese E, Lang CH, Abumrad NN, Moll UM, Talpos GB |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer genetics and cytogenetics [Cancer Genet Cytogenet] 1996 Aug; Vol. 90 (1), pp. 70-4. |
| DOI: |
10.1016/0165-4608(96)00048-9 |
| Abstrakt: |
The cell line PTC-1113A was established from a metastasizing recurrent papillary thyroid cancer. The cell line was growing as monolayer and showed a complex karyotype with chromosome numbers ranging from 30 to 140/metaphase. A proportion of metaphases contained double minutes and/or pulverized chromosomes. Extrachromosomal DNA seemed to originate from a B-group chromosome. A chromosome 4 painting probe hybridized to extrachromosomal material, representing double minutes (dmin) and possibly minutes. In addition, fluorescence in situ hybridization (FISH) with the chromosome 4 library detected a translocation chromosome and a pulverized chromosome originating from chromosome 4. PTC-1113A is, to our knowledge, the single papillary thyroid cancer cell line demonstrating evidence of gene amplification. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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