| Autor: |
Wiley SR; Immunex Research and Development Corporation, Seattle, Washington 98101, USA., Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Immunity [Immunity] 1995 Dec; Vol. 3 (6), pp. 673-82. |
| DOI: |
10.1016/1074-7613(95)90057-8 |
| Abstrakt: |
A novel tumor necrosis factor (TNF) family member has been cloned and characterized. This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity. TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate. The TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members. Both full-length cell surface expressed TRAIL and picomolar concentrations of soluble TRAIL rapidly induce apoptosis in a wide variety of transformed cell lines of diverse origin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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