Secondary dengue infection in schoolchildren in a dengue endemic area in the state of Rio de Janeiro, Brazil.

Autor: da Cunha RV; Departamento de Clínica Médica, Universidade Federal de Mato Grosso do Sul, Rio de Janeiro, Brazil., Dias M, Nogueira RM, Chagas N, Miagostovich MP, Schatzmayr HG
Jazyk: angličtina
Zdroj: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 1995 Nov-Dec; Vol. 37 (6), pp. 517-21.
DOI: 10.1590/s0036-46651995000600008
Abstrakt: A seroepidemiologic survey was carried out in schoolchildren from public schools of the Niterói municipality, state of Rio de Janeiro, Brazil, after a period of sequential epidemics by dengue virus type 1 and 2 (DEN-1 and DEN-2). 450 blood samples were obtained by fingertip puncture and collected on filter paper discs. The hemagglutination inhibition (HAI) test was carried out using DEN-1 and DEN-2 antigens. HAI titres were demonstrated in 66% (297/450) of the sera and the geometric means of the titres were 1/182 and 1/71 for DEN-1 and DEN-2, respectively. Secondary infections were observed in 61% (181/297) of positive cases. Among these, 75% (135/181) were under fifteen years old. No dengue haemorrhagic fever (DHF) was reported in these children. Asymptomatic or oligosymptomatic infections were detected in 56% of the studied population. The absolute and relative frequencies of positive tests by age group and sex did not evidence statistically significant difference. The number of individuals infected probably produced a immunologic barrier responsible for the non occurrence of dengue epidemic in the latter years.
Databáze: MEDLINE