| Autor: |
Brook WJ; European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany., Cohen SM |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1996 Sep 06; Vol. 273 (5280), pp. 1373-7. |
| DOI: |
10.1126/science.273.5280.1373 |
| Abstrakt: |
Subdivision of the limb primordia of Drosophila into anterior and posterior compartments triggers cell interactions that pattern the legs and wings. A comparable compartment-based mechanism is used to pattern the dorsal-ventral axis of the wing. Evidence is presented here for a mechanism based on cell interaction, rather than on compartment formation, that distinguishes dorsal from ventral in the leg. Mutual repression by Wingless and Decapentaplegic signaling systems generates a stable regulatory circuit by which each gene maintains its own expression in a spatially restricted domain. Compartment-independent patterning mechanisms may be used by other organisms during development. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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