| Autor: |
Idusogie E; Department of Chemistry and Biochemistry, University of Notre Dame, Indiana 46556, USA., Rosen E, Geng JP, Carmeliet P, Collen D, Castellino FJ |
| Jazyk: |
angličtina |
| Zdroj: |
Thrombosis and haemostasis [Thromb Haemost] 1996 Mar; Vol. 75 (3), pp. 481-7. |
| Abstrakt: |
The cDNA encoding murine coagulation factor VII (mfVII) was isolated and reconstructed from a lambda Zap cDNA library generated from murine liver mRNA. The cDNA contains 1903 nucleotides spanning 15 bases upstream of the 5'-translation initiation codon, an open reading frame of 1338 nucleotides, 550 nucleotides downstream of the first stop codon and a 3' poly(A) tail. The translation product is composed of a 41-amino acid signal/propeptide region followed by a 405-residue mature protein. The latter is highly homologous to that of human, rabbit, bovine, Rhesus monkey, and canine fVII. All protein domains of hfVII are strictly conserved in mfVII. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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