Novel triterpene sulfates from Fusarium compactum using a rhinovirus 3C protease inhibitor screen.

Autor: Brill GM; Abbott Laboratories, Abbott Park, Il. 60064, USA., Kati WM, Montgomery D, Karwowski JP, Humphrey PE, Jackson M, Clement JJ, Kadam S, Chen RH, McAlpine JB
Jazyk: angličtina
Zdroj: The Journal of antibiotics [J Antibiot (Tokyo)] 1996 Jun; Vol. 49 (6), pp. 541-6.
DOI: 10.7164/antibiotics.49.541
Abstrakt: Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3C protease on a fluorogenic peptide substrate. The compounds were purified by countercurrent and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.
Databáze: MEDLINE