| Autor: |
Schuurman JJ; Department of Nuclear Medicine, Martini Ziekenhuis, Groningen, The Netherlands., Bong SB, Einarsson R |
| Jazyk: |
angličtina |
| Zdroj: |
Anticancer research [Anticancer Res] 1996 Jul-Aug; Vol. 16 (4B), pp. 2169-72. |
| Abstrakt: |
Serum levels of tissue polypeptide specific antigen (TPS), a cytokeratin 18 marker, and CA 15-3 were determined in 42 patients with metastatic breast cancer during routine treatment follow-up. At the time of proved metastatic disease, 86% of the values for TPS were above the upper reference value as compared to 93% for CA 15-3. The combined use of TPS and CA 15-3 increased the overall sensitivity. The levels of the tumor markers followed the course of disease during a follow-up period of 6-10 months, even though the dynamics of the changes of tumor markers levels differed in some patients. An increase in the tumor marker level of 25% or more was seen in 60% (TPS) and 52% (CA 15-3), respectively of the studied patients. TPS appeared to indicate changes faster than CA 15-3. The overall results of this study suggest the combined use of TPS and CA 15-3 in the monitoring of breast cancer patients is preferable. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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