| Autor: |
Di Biagio E; Immunology Service, Instituto de Oncología y Hematología, Ministry of Health, Caracas, Venezuela., Sánchez-Borges M, Desenne JJ, Suárez-Chacón R, Somoza R, Acquatella G |
| Jazyk: |
angličtina |
| Zdroj: |
International archives of allergy and immunology [Int Arch Allergy Immunol] 1996 Jul; Vol. 110 (3), pp. 244-51. |
| DOI: |
10.1159/000237294 |
| Abstrakt: |
In order to clarify the mechanisms of the eosinophilia frequently observed in patients with Hodgkin's disease (HD), 18 patients and 16 age- and sex-matched controls were studied. Increased eosinophil numbers in peripheral blood and serum IgE, as well as decreased cell-mediated immunity were present in HD patients compared with control individuals. Advanced disease was accompanied by lower eosinophil levels, increased IgE, and lower CD4+ T cell counts in peripheral blood. Eosinophilia correlated with CD4+ T cell counts, suggesting that eosinophil production could be under CD4+ T cell control. GM-CSF production in vitro by Phytohemagglutinin-stimulated mononuclear cells was significantly lower in HD patients with eosinophilia. On the other hand, an eosinophil-survival-enhancing activity was found in sera and culture supernatants from controls and HD patients; this activity was stronger for HD patients and was higher for those with eosinophilia. Furthermore, this activity was completely abolished by preincubation with monoclonal antibodies to IL-5, but not with normal mouse serum. Our results suggest that defects of cell-mediated immunity present in patients with HD are accompanied by a predominant type 2 cytokine profile. IL-5 is involved in the increased eosinophil production observed in these patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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