Double-blind evaluation of ritodrine sustained release for oral maintenance of tocolysis after active preterm labour.

Autor: Holleboom CA; Department of Obstetrics and Gynaecology, bronovo Hospital, The Hague, The Netherlands., Merkus JM, van Elferen LW, Keirse MJ
Jazyk: angličtina
Zdroj: British journal of obstetrics and gynaecology [Br J Obstet Gynaecol] 1996 Jul; Vol. 103 (7), pp. 702-5.
DOI: 10.1111/j.1471-0528.1996.tb09841.x
Abstrakt: Objective: To evaluate the effect of ritodrine sustained release capsules for maintaining uterine quiescence after successful treatment of active preterm labour.
Design: Multicentre placebo-controlled trial.
Setting: Five teaching hospitals in the Netherlands.
Participants: Women (n = 95) at less than 35 weeks of gestation in whom active preterm labour had been stopped with intravenous ritodrine.
Interventions: Women received either two 40 mg ritodrine sustained release capsules (n = 50) or identical placebo capsules (n = 45) three times a day for seven days.
Results: The proportion of women who received another course of active treatment was significantly smaller with the sustained release than with placebo (1 of 50 versus 11 of 45: P = 0.003) as was the number delivering because of preterm labour during treatment (0 of 50 versus 4 of 45: P = 0.04). There were no other significant differences between the two groups.
Conclusions: Maintenance treatment with ritodrine sustained release capsules after arrest of preterm labour reduces the risk of recurrences of preterm labour that necessitate treatment or precipitate delivery.
Databáze: MEDLINE
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