Randomized, double blind comparison of brand and generic antibiotic suspensions: I. A study of taste in adults.
| Autor: | Samulak KM; St. John's University College of Pharmacy, Jamaica, NY, USA., El-Chaar GM, Rubin LG |
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| Jazyk: | angličtina |
| Zdroj: | The Pediatric infectious disease journal [Pediatr Infect Dis J] 1996 Jan; Vol. 15 (1), pp. 14-17. |
| DOI: | 10.1097/00006454-199601000-00003 |
| Abstrakt: | Background: A belief that brand oral liquid medications taste better than their generic counterparts may influence prescribing habits among pediatricians. Methods: We undertook a prospective, randomized, double blinded, comparative evaluation of the taste of brand and generic erythromycin ethylsuccinate, cephalexin monohydrate, erythromycin ethylsuccinate/sulfisoxazole, penicillin V potassium and trimethoprim-sulfamethoxazole in 42 adult volunteers. Subjects tasted one class of brand and generic antibiotics and rated them according to smell, texture, taste and aftertaste. Results: At least one generic preparation of cephalexin, erythromycin ethylsuccinate/sulfisoxazole and penicillin V potassium was rated equal in taste to the respective brand name products. However, brand erythromycin estolate and trimethoprim-sulfamethoxazole name brand suspensions rated significantly higher than the other products tested. Conclusions: Based on our results brand name oral antibiotic formulations do not necessarily taste better than their generic counterparts. |
| Databáze: | MEDLINE |
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