| Autor: |
Warnich L; Department of Genetics, University of Stellenbosch, South Africa., Meissner PN, Hift RJ, Louw JH, van Heerden CJ, Retief AE |
| Jazyk: |
angličtina |
| Zdroj: |
Human genetics [Hum Genet] 1996 May; Vol. 97 (5), pp. 690-2. |
| DOI: |
10.1007/BF02281885 |
| Abstrakt: |
The gene for variegate porphyria (VP), an autosomal dominant disease with a high prevalance in South Africa, evidently due to a founder effect, was previously mapped to chromosome 14q32. In the current study this localization was evaluated by linkage and haplotype analyses using microsatellite markers spanning a region of more than 20 cM on chromosome 14q32. In many recent studies linkage disequilibrium between disease and marker loci has been utilized to map genes in founder populations, but we could not find any association between VP and the markers used in this study. Our data suggest that the allocation of VP to chromosome 14q32 may be incorrect. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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