| Autor: |
Klimek JJ, Nightingale C, Lehmann WB, Quintiliani R |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of infectious diseases [J Infect Dis] 1977 Jun; Vol. 135 (6), pp. 999-1002. |
| DOI: |
10.1093/infdis/135.6.999 |
| Abstrakt: |
Twenty-eight children aged five to nine years with chronic serous otitis media received a single dose of either ampicillin or amoxicillin by the oral route 1-2 hr before the removal of middle ear fluid by ventilation tubes inserted through the tympanic membrane. At the time middle ear fluid was obtained, a sample of blood was drawn from the patient, and levels of antibiotic in both specimens were microbiologically assayed by a disk diffusion method. Levels of amoxicillin (mean+/-standard error [SE], 1.48+/-1.6 microng/ml) in middle ear fluid were consistently and significantly higher (P less than 0.05) than levels of ampicillin (mean+/-SE, 6.2+/-5.0 microng/ml). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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