| Autor: |
de Vos JW; Department of Pharmacology, University of Amsterdam, The Netherlands., Geerlings PJ, van den Brink W, Ufkes JG, van Wilgenburg H |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of clinical pharmacology [Eur J Clin Pharmacol] 1995; Vol. 48 (5), pp. 361-6. |
| DOI: |
10.1007/BF00194951 |
| Abstrakt: |
In a closed metabolic ward the pharmacokinetics of methadone and its primary metabolite (EDDP) were studied in 20 long-term opiate addicts. After administration of the daily oral dose of methadone HCl (mean 60 mg, range 10-225 mg) blood samples were taken and analysed, using a newly developed high-performance liquid chromatography (HPLC) method. The steady-state plasma concentrations of the 20 subjects varied from 65-630 ng x ml(-1) and from 5 to 55 ng x ml(-1), whereas the peak concentrations were 124-1255 ng x ml(-1) and 10-301 ng x ml(-1) for methadone and the AUC(0-24 h) for EDDP varied from 5.9 to 44.6, indicating interindividual differences in metabolic activity. In 19 out of 20 subjects the pharmacokinetics of methadone are best described using a two-compartment model. The mean body clearance was 1.64 ml x min(-1) x kg(-1), whereas the mean elimination rate constant (beta) and plasma half-life (t1/2beta) were 0.026 x h(-1) (range 0.013-0.053 x h(-1)) and 31.2 h (range 13-53 h), respectively. Differences of gender were also found. A poor correlation was found between the methadone dose and the steady-state level. A much better correlation was found between the normalized steady-state level and the body clearance. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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