| Autor: |
Leet JE; Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA., Schroeder DR, Golik J, Matson JA, Doyle TW, Lam KS, Hill SE, Lee MS, Whitney JL, Krishnan BS |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1996 Mar; Vol. 49 (3), pp. 299-311. |
| DOI: |
10.7164/antibiotics.49.299 |
| Abstrakt: |
The structure of the antitumor antibiotic himastatin was determined using a combination of spectroscopic and chemical degradation techniques. Himastatin is a unique dimeric cyclohexadepsipeptide joined through a biphenyl linkage between two oxidized tryptophan units. The gross structure of the dimer was established through degradative ozonolysis. Himastatin consists of D-valine, D-threonine, L-leucine, L-alpha-hydroxyisovaleric acid, (3R,5R)-5-hydroxypiperazic acid, and (2R,3aR,8aR)-3a-hydroxyhexahydropyrrolo[2,3b]indole 2-carboxylic acid subunits. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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